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Document Type |
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Project |
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Document Title |
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Quantization of Phenolic, Squalene and Measuring the Antioxidant Potential of Different Types of Olive Oils Local vs Imported تقدير الفينولات، السكوالين، وقياس احتمالية |
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Subject |
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Quantization of Phenolic, Squalene and Measuring the Antioxidant Potential of Different Types of Olive Oils Local vs Imported |
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Document Language |
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Arabic |
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Abstract |
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This study concentrates on the chemoprevention of cancer as a result of the health benefits of the Mediterranean diet, of which olive oil is a major component. Recent studies have shown that olive oil contains an abundance of phenolic antioxidants including simple phenols (hydroxytyrosol, tyrosol), aldehydic secoiridoids, flavonoids and lignans (acetoxypinoresinol, pinoresinol). All these phenolic substances are potent inhibitors of reactive oxygen species attack on, e.g. salicylic acid, 2-deoxy-guanosine. Currently there is growing evidence that reactive oxygen species are involved in the etiology of fat-related neoplasms such as cancer of the breast and colorectal. A plausible mechanism is a high intake of ω-6 polyunsaturated fatty acids which are especially prone to lipid peroxidation initiated and propagated by reactive oxygen species, leading to formation (via, α, β-unsaturated aldehydes such as trans-4-hydroxy-2-nonenal) of highly pro-mutagenic exocyclic DNA adducts. Previous studies have shown that the colonic mucosa of cancer patients and those suffering from predisposing inflammatory conditions such as ulcerative colitis and Crohn's disease generates appreciable higher quantities of reactive oxygen species compared with normal tissue. In our ongoing cancer chemopreventive and human health studies, we have a particular interest in the health benefit of olive oil, and therefore the aim of this study is not only to quantitate the phenolic and squalene content of different types of olive oils locally found and compared to different imported types, but also to asses their antioxidant potential. By doing this project, our laboratory will be one of center in Saudi Arabia that will be able to participate in solving any problems related to the health benefits of olive oil. |
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Publishing Year |
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1428 AH
2007 AD |
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Added Date |
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Monday, July 12, 2010 |
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Researchers
| طه عبدالله قمصاني | Kumosani, Taha Abdullah | Investigator | Doctorate | |
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