Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Synthesis and characterization of some new heterocycles incorporating the 1-Phenyl-5-(2-thienyl)pyrazole moiety تشييد مركبات حلقية غير متجانسة محتوية على نواتى الثينيل بيرازول |
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Subject |
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Organic Chemistry |
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Document Language |
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English |
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Abstract |
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1-Phenyl-3-(2-thienyl)-1H-pyrazole-5-carbohydrazide 4 was prepared from 2-acetylthio- phene by reaction with diethyl oxalate and phenylhydrazine followed by hydrazine hydrate. The reaction of the hydrazide 4 with phthalic anhydride, aromatic aldehydes, and alkene derivatives gave imide 5, hydrazones 6a-d, and bis-pyrazoles 7 and 8, respectively, while its reaction with phenyl isothiocyanate led to thiosemicarbazide 9. The reaction of the latter with ethyl bromoacetate and phenacylbromide afforded 4-thiazolidinone 10 and 1,3-thiazole 11 derivatives, respectively. Reaction of 4 with carbon disulfide in the presence of potassium hydroxide gave potassium hydrazinecarbodithioate derivative 12, which was used as a starting material in the preparation of 2-thioxothiazol-3(2H)-yl)-5-(2-thienyl)-1H-pyrazole-3-carboxamide 14; 1,3,4-thiadiazol-2(3H)-ylidene)-1-phenyl-5-(2-thienyl)-1H-pyrazole-3- carbohydrazides 16a-c; 4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl) pyrazole derivative 13; Schiff bases 17a,b; and 1,2,4-triazolo[3,4-b][1,3,4] thiadiazine derivatives 18 and 19a-e |
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ISSN |
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1042-6507 |
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Journal Name |
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Phosphorus, Sulfur and Silicon and the Related Elements |
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Volume |
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185 |
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Issue Number |
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2 |
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Publishing Year |
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1431 AH
2010 AD |
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Article Type |
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Article |
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Added Date |
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Saturday, December 25, 2010 |
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Researchers
| بكر فتحى عبد الوهاب | Abdel-Wahab, Bakr Fathi | Researcher | Doctorate | |
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