Document Details Document Type : Article In Journal  Document Title : Mathematical modeling as a tool for improving the action of drugs والنمذجة الرياضية كأداة لتحسين العمل من المخدرات   Subject : Bio Mathematics  Document Language : English  Abstract : Recently the Biomathematics is an emerging field which has enabled the development of a range of new theories with significant problems of disease progression and control. The aim of this review is to discuss the development of mathematical models for the drug release by commonly used drug delivery system. Mathematical models may be considered as an instrumental in increasing the understanding of drug-patient interactions. Among various developed methods a mathematics based approach, termed ‘Z-method’, has been devised for increasing efficacy/toxicity ratio of chemotherapeutic agents and this method suggests that safety of cell-cycle-specific drugs. Experimental verification of the Z-method in mice gives a proof-of-concept for the utility of biomathematics in drug development. Apart from this various models has been described in this review which are developed for various drug delivery systems. Based on these concepts, existing mathematical models would be utilized as well as more advanced mathematical models would be developed, for better understanding of the drug release and disease prognosis. Biomathematics has the power of integrating vast biomedical and pharmaceutical knowledge into a concise formal language that enables intensive calculations of the outcomes of complex processes. These calculations justify their use for rational treatment design at any stage, when partial preclinical results collected in several species are to be used for predicting the human response.  ISSN : 1012-1319  Journal Name : Science Journal  Volume : 4  Issue Number : 2  Publishing Year : 1429 AH 2008 AD  Article Type : Article  Added Date : Monday, December 27, 2010  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email محرم علي خان Khan, Moharram Ali Researcher Doctorate mkhan91@gmail.com Files File Name Type Description  28574.pdf pdf   Back To Researches Page