Document Details

Document Type : Article In Journal 
Document Title :
Synthesis and biological evaluation of new 3- trifluoromethylpyrazolesulfonyl-urea and thiourea derivatives as antidiabetic and antimicrobial agents
Synthesis and biological evaluation of new 3- trifluoromethylpyrazolesulfonyl-urea and thiourea derivatives as antidiabetic and antimicrobial agents
 
Subject : Chemistry 
Document Language : English 
Abstract : Fluorinated pyrazoles, and benzenesulfonylurea and thiourea derivatives as well as their cyclic sulfonylthioureas 2-18 were prepared as hypoglycemic and antibacterial agents. The chemistry involves the condensation of 4-hydrazino benzenesulfonamide hydrochloride with 1-trifluoromethyl diketones 1 to give pyrazole derivatives 2 which upon bromination gave the bromopyrazole 3. Reaction of 2 or 3 with isocyanates and isothiocyanates gave the corresponding ureas 4 and 5 and thioureas 6 and 7. Cyclization of thiourea derivatives with ethyl bromoacetate, ethyl β-bromopropionate, 1,3-dichloroacetone and α-bromoacetophenone yielded the corresponding 4-oxothiazolidines 8 and 9, 4-oxo-5,6-dihydrothiazine 10, 5-oxo-4,5-dihydrothiazines 11 and 12 and thiazolines 13 and 14. Preliminary biological screening of the prepared compounds revealed significant antidiabetic and antibacterial activities. 
ISSN : 0022-1139 
Journal Name : Journal of Fluorine Chemistry 
Volume : 132 
Issue Number : 2 
Publishing Year : 1432 AH
2011 AD 
Article Type : Article 
Added Date : Saturday, March 3, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
حسن مصطفى فيض اللهFaidallah, Hassan MostafaResearcherDoctorateHFAIDALLAH@kau.edu.sa
سلمان أحمد خانKhan, Salman AResearcherDoctoratesahmad_phd@yahoo.co.in
عبدالله محمد عسيريAsiri, Abdullah MohamedResearcherDoctorateaasiri2@kau.edu.sa

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