Document Details

Document Type : Thesis 
Document Title :
Preparation and Characterization of Modified Chitosan for Bioactive Applications
تحضير وتوصيف الكيتوزان المحور للتطبيقات الحيوية
 
Subject : Organic Chemistry 
Document Language : Arabic 
Abstract : The thesis is aiming to prepare new Chitosan derivatives of known important and beneficial characteristics in medicinal and bio-applications. The current study includes preparation of some blends of Chitosan with different organic compounds such as carbohydrates (mono-, di- and polysccharides), aromatic aldehydes (benzaldehyde, salicylaldehyde and p-nitrobenzaldehyde) and aliphatic aldehydes (acetaldehyde and glyoxalic acid), carboxylic acids (succinic acid and dimercaptosuccinic acid) and some acid anhydrides (acetic anhydride and phtahlic anhydride). Water-soluble Chitosan derivative with glycidyltrimethylammonium chloride has been also prepared. The obtained products have been crosslinked by using glutaraldehyde and their ability for utilization in different applications has been studied. Chitosan has been also treated with different organic solvents such as alcohols, petroleum ethers and benzene and the impact of such treatment on the surface area and particle size of Chitosan has been reported. This treatment reflected on the yield of the reactions of Chitosan and its derivatives and on the possibility to prepare Chitosan particles on the micro- and nano-level as well. The modified Chitosans have been characterized through spectroscopic, microscopic and thermal analyses. The obtained materials have been applied for separation and isolation of some transition metal ions from their aqueous solutions. Aqueous solution of copper, cobalt, nickel and lead nitrates were used as representative examples of the transition metal ions. The polymer capacity of such metal ions has been calculated after back determination of the corresponding metal ion concentration in the aqueous solutions used for treatment by using ICP-AES analysis. Biological activity of some Chitosan derivatives on some types of micro-organism such as bacteria, yeasts and fungi has been investigated in two media suitable to the investigated micro-organism either with or without carbon source. Aspergillus niger, Burkholderia cepaci and Candida albicans were used as representative examples for the micro-organisms. The effect of Chitosan derivatives on the micro-organism has been explained and justified. 
Supervisor : Magdy Y. Abdelaal 
Thesis Type : Master Thesis 
Publishing Year : 1432 AH
2011 AD 
Number Of Pages : 190 
Co-Supervisor : Tariq R. Sobahi 
Added Date : Wednesday, August 28, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
حصة فهد الشريفAl Shareef, Hossa FahadInvestigatorDoctorate 

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