Document Details

Document Type : Thesis 
Document Title :
Collagen Gene (COLI-α1) Polymorphism in Patients with Keloid in Jeddah
التعدد الشكلي لاليلات جين الكولاجين ألفا-1 في مرضى الجدرية في جدة
 
Subject : biological sciences department 
Document Language : Arabic 
Abstract : Keloid scar is the fifth most common skin disease in adult black patients in the United Kingdom and the most common skin disease among ethnic Chinese patients in Asia. It is a benign hyperproliferative growth of dermal fibroblasts characterized by an abnormal excessive deposition of extracellular matrix components especially collagen. It is well known that keloid can be triggered in genetically susceptible individuals. Collagen synthesis is 20 times more in keloid compared to normal skin. In the current study, the association between −1997G/T (rs1107946) and COL1A1 Sp1 +1245 G/T (rs1800012) polymorphisms and incidence of scars in Jeddah city population was evaluated. The distribution of alleles frequency of the −1997G/T (rs1107946) and Sp1 +1245G/T (rs1800012) polymorphisms in 84 volunteers (43 males and 41 females) was determined. Genotypes were determined for all subjects by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for the two single nucleotide polymorphisms SNPs. When comparing the two groups, results demonstrated that there is a higher significant difference between genotype distribution and formation type (P=0.00) which means that most of scars tend to be GG type and most of normal are of GT type in -1997G/T (rs1107946) while there were no significant association between formation type and genotype (P= 0.08) in SP1 +12451997G/T (rs1800012). In contrast, when comparing the two groups according to gender, results demonstrated that there is a higher significant difference between genotype distribution and formation type (P=0.00) in -1997G/T (rs1107946) in females group while there were no significant association between formation type and genotype in males group (P= 0.17) while there were no significant association between scars type and genotype in SP1 +1245G/T (rs1800012) (P= 0.22) in both groups. In conclusion, this study replicates and strengthens the evidence for association between polymorphisms of −1997G/T and +1245 G/T of COL1A1 gene in the genetic aetiology of keloid scars. 
Supervisor : Dr. Sabah Abdulaziz Linjawi 
Thesis Type : Master Thesis 
Publishing Year : 1434 AH
2013 AD 
Co-Supervisor : Dr. Sanaa AL- sayid Tork 
Added Date : Wednesday, September 4, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ريسه موسى شيبهshaibah, Raysa mousaResearcherMaster 

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